CBD As Treatment For Rheumatoid Arthritis, Others

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CBD As Treatment For Rheumatoid Arthritis, Others
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There are many maladies that plague our existence these days. It seems that more and more are being ‘found’, and it is wonderfully convenient that new medications are being presented to help combat these strange dis-eases for ‘our benefit’. Getting older is inherently dangerous and full of health issues…or so our Health Care (read: disease management) tells us is so.

What we are here to tell you today is that this is NOT the case. In fact, we have enough knowledge and resources that ALL of humanity should be living a full, healthy, and clean lifestyle. This is becoming increasingly difficult, especially with the advent of GMO’s, pesticides, BPA, uranium, cesium, phthalates, Rx’s, Reality TV, wifi…you get the picture. We are under a constant barrage of toxins, some external, some internal.

Cancer has become the status quo. Pain is now the new M.O. Alzheimer’s will help you forget all of it.

There are many options available for all of us to turn to, if only much of the truth were not suppressed. And with the internet, one of our last bastions of freedom, we are able to spread information far and wide. Which is the point of this message today.

Many health issues can be handled without the need for dangerous pharmaceuticals, and much of the new research regarding natural remedies has been focused on cannabidiol, or CBD.

In the study, Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress, the author takes an umbrella approach and analyzes CBD within the context of oxidative stress and associated inflammation.

The following are excerpts from each dis-ease related section of his analysis:

CBD’s Actions on Immune Cells

A recent study assessed the impact of repeated administration of relatively low levels of CBD to adult male Wistar rats on peripheral blood lymphocyte subset distribution [32]. At 2.5 mg/kg/day for 14 days, CBD did not produce lymphopenia, but increased the total number of natural killer T (NKT) cells and percentage numbers of NKT and natural killer (NK) cells. A dose of 5 mg/kg/day did have a lymphopenic effect, but by reducing B, T, Tc and Th lymphocytes. Thus, CBD would appear to suppress specific immunity, while enhancing nonspecific antitumor and antiviral immune response.


CBD and Hypertenstion

Although CBD has not been considered for treating hypertension, a parallel between the role of microglia in diabetes and hypertension deserves mention. Activation of microglia within the paraventricular nucleus (PVN) was recently shown to contribute to neurogenic hypertension resulting from chronic angiotensin II infusion in the rat [46]. Microglia activation was associated with enhanced expression of pro-inflammatory cytokines, the acute administration of which into the left ventricle or PVN resulted in increased blood pressure. The hypertensive action of angiotensin II infusion could be blocked by overexpression of IL-10 in the PVN or intracerebroventricular infusion of minocycline, supporting the involvement of ROS (reactive oxygen species).

CBD on Pain

The antinociceptive effects of CBD were associated with less of an increase in microglial density and p38 MAPK activity in the dorsal spinal cord. Finally, the anti-inflammatory and immunosuppressive actions of CBD may be of use in treating rheumatoid arthritis and the associated pain

CBD on Diabetes and Diabetic Complications

CBD attenuated diabetes-induced activation in the heart of the key pro-inflammatory transcription factor, NF-κB and its consequences, e.g. expression of ICAM-1, iNOS, VCAM-1, and TNFα. These observations underscore the point that CBD likely attenuates inflammation far beyond its antioxidant properties per se. CBD also reduced high glucose-induced increases in both cytosolic and mitochondrial reactive oxygen and nitrogen species generation in primary human cardiac myocytes, which was accompanied by reduced NF-κB activation and cell death. These findings indicate that CBD may have great therapeutic potential in alleviating cardiac complications of diabetes.

CBD and Ischemia Reperfusion Injury

In rats, treatment with CBD for 7 days following a 30 minute occlusion of the left anterior descending coronary artery markedly reduced infarct size, myocardial inflammation and IL-6 levels and preserved cardiac function. In addition, the number of leukocytes infiltrating the border of the infarcted area was dramatically reduced. CBD has been shown to inhibit stimulated migration of neutrophils. CBD treatment was also recently shown to reduce neutrophil migration in a rat model of periodontitis.

CBD and Depression

CBD is reported to have anti-depressive actions, the basis for which is not established although activation of 5-HT1A receptors may be involved at least at higher concentrations. Growing evidence in recent years has implicated pro-inflammatory cytokines, free radical species, and oxidants in the etiology of depression. One explanation is that the resultant oxidative stress adversely affects glial cell function and leads to neuron damage in the brain.

CBD and Neurodegenerative Diseases

CBD was shown to have a protective effect on cultured rat pheocromocytoma PC12 cells exposed to Aβ [72,73]. In a concentration-dependent manner, CBD increased cell survival, while decreasing ROS and nitrite production, lipid peroxidation, and iNOS protein expression. CBD was shown to have anti-inflammatory actions in vivo in a mouse model of Alzheimer’s neuroinflammation induced by injection of human Aβ into the hippocampus. CBD dose-dependently attenuated Aβ-induced glial fibrillary acidic protein (GFAP) mRNA, iNOS and IL-1β protein expression, and NO and IL-1β release [74]. In a recent study, CBD was found to protect against amphetamine-induced oxidative protein damage in a rat model of mania and to increase brain-derived neurotrophic factor (BDNF) expression levels in the reversal protocol [75]. Results of these preclinical studies are persuasive and support the need for double-blind placebo controlled trials to assess the therapeutic utility of CBD in patients with neurodegenerative diseases.

CBD and Obesity and the Metabolic Syndrome

Although tonic activation of CB1 receptors by endocannabinoids is implicated in the development of abdominal obesity and CB1 antagonists and inverse agonist reduce obesity, their clinical use is problematic due to serious neuropsychiatric effects. Given its anti-inflammatory actions and PPARγ agonism, CBD might serve as the basis for design of a new anti-obesity drug.

CBD and Atherosclerosis

Such tantalizing findings have fueled the idea that the endocannabinoid system may be a avenue for further drug development in dealing with atherosclerosis, likely involving a role for CBD as well.

CBD does seem to be a wonderful starting point for further drug development, based upon not only its anti-oxidant properties, but also upon it’s anti-inflammatory actions on immune cells, such as macrophages and microglia. CBD also has the advantage of not having psychotropic side effects. “Studies on models of human diseases support the idea that CBD attenuates inflammation far beyond its antioxidant properties, for example, by targeting inflammation-related intracellular signaling events,” according to the study’s author George W. Booz. “The details on how CBD targets inflammatory signaling remain to be defined. The therapeutic utility of CBD is a relatively new area of investigation that portends new discoveries on the interplay between inflammation and oxidative stress, a relationship that underlies tissue and organ damage in many human diseases.”

 

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